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In the HdhQ150 mouse model of HD, in vivo MRI was employed at two time points, before and after the onset of motor signs, to assess brain macrostructure and white matter microstructure. Ex vivo MRI, immunohistochemistry, transmission electron microscopy and behavioural testing were also conducted. Global brain atrophy was found in HdhQ150 mice at both time points, with no neuropathological progression across time and an elective sparing of the cerebellum.
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Quantitative trait loci (QTL) analysis identified a total of 131 QTL, and QTL meta analysis found four integrated QTL across the growth systems. Integration reduced the confidence interval by 41%. QTL for root and shoot biomass were co located on chromosome A3 and for lateral root emergence were co located on chromosomes A4/C4 and C8/C9.
Warren says he wishes the solution were as simple as just taking folic acid. For individuals with autism and their families would be a whole lot easier if we had simple answers about cause and risk, he says. Reality is, autism is a complex disorder and our best answers about causes and treatment are going to be complex as well.
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