Rationale: Outcome after intracerebral hemorrhage remains poor. Tranexamic acid is easy to administer, readily available, inexpensive, and effective in other hemorrhagic conditions.Aim: This randomized trial aims to test the hypothesis that intravenous tranexamic acid given within 8 h of spontaneous intracerebral hemorrhage reduces death or dependency.Design: Phase III prospective double blind randomized placebo controlled trial. Participants within 8 h of spontaneous intracerebral hemorrhage are randomized to receive either intravenous tranexamic acid 1 g 10 min bolus followed by 1 g 8 h infusion, or placebo.Sample size estimates: A trial of 2000 participants (300 from start up phase and 1700 from main phase) will have 90% power to detect an ordinal shift of the modified Rankin Scale with odds ratio 0.79.Study outcomes: The primary outcome is death or dependency measured by ordinal shift analysis of the 7 level mRS at day 90.
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When police officials try to console her by telling her that she has saved “a lot of people a lot of grief,” she replies, “I don’t think that’s going to help me sleep nights.” Ray extends and underscores the moment. One is inescapably drawn to the conclusion that the director is referring to the nascent Hollywood witch hunts, especially since no scene like this exists in the book. Ironically, Ray, a former Communist Party member, would “name names” in the early 1950s before a secret congressional hearing..
The Internet has begun to blow up power elite memes the fear based promotions by which the Anglo American elites have sought to control society. Literally trillions of dollars have been thrown into an effort to create a network of political structures (UN, IMF, BIS, etc.), think tanks, educational facilities and popular media that can amplify these dominant social themes. It looks like a natural process but in fact, it is an entirely artificial one..